Wednesday, July 13, 2016

July 13, 2016 Wednesday

Fearing infection in the dorsum of the hand, started
Tab Cefuroxime 500 mg BD

This drug prevents bacteria from synthesizing their cell wall.

It specifically blocks synthesis of peptidoglycan in the cell wall.

But does it do so?

By mimicry, the oldest weapon the warfare.

The last step of synthesis of peptidoglycan involves cross-linking
at D-alanine-D-alanine end of peptides.

Cefuroxime mimics this sequence and thereby mistakenly 
the protein binding protein gets to working with this molecule
rather than the originally intended peptidoglycan precursors 
of the bacterial cell wall.   



Dmitri Mendeleev in his landmark presentation of 1869 made the following 8 assertions:

1. The elements when arranged according to their atomic weights exhibit a periodicity (something that repeats itself).

2. Elements that have similar chemical properties either have similar atomic weights or exhibit atomic weight of regular increments.

3. The arrangement of elements that were grouped according to their atomic weights corresponds to their valencies.
Eg. Li, Be, B, C, N, O, and F

4. The elements that are most widely diffused in nature have small atomic weights.
(Here we have a hint of stellar nucleosynthesis and the big bang).

5. The magnitude of the atomic weight determines the character of the element.

6. Discovery of unknown elements is to be expected by the gaps in his table.
(Example. 2 elements similar to aluminum and silicon whose atomic weights lie between 65 and 75).

This was the ultimate strength of his periodic table!

7. The atomic weight of an element may need to be changed by the knowledge of its adjacent elements.

(He was referring to Tellurium 52 which is surrounded by Selenium 34 above and Polonium 84 below).

8. Certain chemical properties can be predicted from their atomic weights.

This was the moment of prescient synthesis which can be equalled to Newton's understanding of gravity as the same force that makes the apple falls and moon to orbit the earth.

Mendeleev soon thereafter published his version of the periodic table.

Mendeleev had high esteem for the Sanskrit grammarians (Panini of the 4th century BC in particular) of ancient India and to show his appreciation he gave Sanskrit names and prefixes to the missing elements.

He used the prefixes eka, dvi, and tri (Sanskrit one, two, three) in naming these unknowns.

Some say that the similarities between the periodic table and Panini's phonological patterning of sounds is remarkably striking.

Panini's grammar is the world's first formal system developed centuries before the formal mathematical logic whose foundations were laid by the German mathematician and logician Gottlob Frege in early 1900s.

Fascinating stuff, isn't it mon ami?

Stay tuned to the voice of an average storytelling chimpanzee or login at http://panarrans.blogspot.in/

Good night mon ami and my fellow cousin ape.

No comments:

Post a Comment